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Angioedema

Sudden swelling deep under the skin — usually around the eyes, lips, hands, or genitals. Can be hereditary, drug-induced, or part of an allergic reaction. Throat swelling is an emergency.

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Dr. Payel Gupta

Medically Reviewed

Dr. Payel Gupta

Triple Board-Certified Allergist & Immunologist

Last reviewed: May 2026

Overview

Angioedema is deep swelling under the skin, often affecting the face, lips, tongue, or throat. It can be allergic (histamine-mediated) or non-allergic (e.g., bradykinin-mediated).

symptoms

  • Swelling of face, lips, tongue, or throat
  • Swelling of hands, feet, or genitals
  • Abdominal pain if gut involved
  • Can occur with hives (urticaria) or alone

triggers

  • Foods
  • Medications
  • Insect stings
  • Unknown (idiopathic)
  • ACE inhibitors (non-allergic type)

testing

  • Allergy testing when allergic cause suspected
  • C1 esterase inhibitor and complement levels when hereditary or acquired angioedema considered

treatment

acute

  • Epinephrine if airway or anaphylaxis
  • Antihistamines
  • Corticosteroids
  • H2 blockers

chronic

  • Identify and avoid triggers
  • Antihistamines
  • Specialized therapy for hereditary/acquired angioedema

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