Nasal Sprays · Combination nasal antihistamine + corticosteroid
Dymista: Prescription Nasal Spray (Azelastine + Fluticasone)
Brand names: Dymista
Last reviewed June 9, 2026 · Medically reviewed by AllergyCenter
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Dymista is the go-to prescription nasal spray for moderate-to-severe allergic rhinitis. It combines azelastine (a fast-acting antihistamine) with fluticasone (a powerful steroid) in a single bottle — giving you both immediate relief from sneezing and itching plus long-term control of inflammation and congestion.
Multiple clinical trials have shown Dymista outperforms either azelastine or fluticasone used alone. It's prescription only — an allergist will review whether it's the right next step after OTC sprays.
Quick Facts
- Generic name
- Azelastine hydrochloride + fluticasone propionate
- Brand names
- Dymista
- Drug class
- Nasal antihistamine + nasal corticosteroid combination
- Form
- Metered nasal spray
- OTC or Rx
- Prescription only
- Typical adult dose
- 1 spray in each nostril twice daily
- Age range
- 6+
- Onset of action
- Within hours for the antihistamine component; days for full steroid effect
TL;DR — At a Glance
- ·Dymista combines two nasal allergy medications (azelastine + fluticasone) in one spray.
- ·Outperforms Flonase or Astepro alone in clinical trials.
- ·Standard adult dose: 1 spray in each nostril twice daily.
- ·Prescription only — typically used when OTC sprays don’t provide enough relief.
- ·Common side effects: bitter taste (from azelastine), nosebleeds, headache.
Get a Dymista prescription
If OTC sprays like Flonase or Astepro aren’t fully controlling your nasal allergies, Dymista may be the next step. An allergist can review your case and prescribe it after a $49 async consult.
Medical Disclaimer: This guide is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a licensed healthcare provider. Do not start, stop, or change any medication without consulting a qualified provider.